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. 2013 Dec 5;8(12):e81504. doi: 10.1371/journal.pone.0081504

Figure 1. MAP2K4's role in prostate cancer metastasis.

Figure 1

A. The domains of MAP2K4. MAP2K4 has three distinct domains; the kinase domain (KD) is involved in the actual kinase activity, the docking domain (D) mediates binding to downstream MAPKs and the domain of versatile docking (DVD) mediates interactions with upstream activators. B. Genistein inhibits MAP2K4 in human prostate cancer cells, thereby inhibiting phosphorylation of downstream effector proteins leading to down-regulation of MMP-2 expression in vitro and in prostate tissue in humans, inhibition of cell invasion, and inhibition of human prostate cancer metastasis in mice.