Table 2.
Differentially expressed genes in wild-type and U19/EAF2 knockout ventral prostate
| ID | WT intensity | KO intensity | log2(KO/WT) | Fold-change KO vs WT | Diff expr | Gene name |
|---|---|---|---|---|---|---|
| 1416497_at | 1364.2 | 3584.2 | 1.39 | 2.6 | KO > WT | protein disulfide isomerase associated 4 |
| 1417225_at | 913.2 | 2773.2 | 1.6 | 3 | KO > WT | ADP-ribosylation factor-like 6 interacting protein 5 |
| 1417594_at | 333.9 | 967.7 | 1.54 | 2.9 | KO > WT | G kinase anchoring protein 1 |
| 1417867_at | 170.9 | 629.2 | 1.88 | 3.7 | KO > WT | complement factor D (adipsin) |
| 1418666_at | 33.9 | 99.6 | 1.55 | 2.9 | KO > WT | pentraxin related gene |
| 1419554_at | 372.1 | 939.8 | 1.34 | 2.5 | KO > WT | CD47 antigen (Rh-related antigen, integrin-associated signal transducer) |
| 1419946_s_at | 408.9 | 1083.9 | 1.41 | 2.7 | KO > WT | predicted gene 5865; RAB2A, member RAS oncogene family |
| 1420037_at | 780.4 | 2270.4 | 1.54 | 2.9 | KO > WT | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1 |
| 1420125_at | 30.3 | 172 | 2.51 | 5.7 | KO > WT | T-cell leukemia translocation altered gene |
| 1421163_a_at | 371.3 | 2100.2 | 2.5 | 5.7 | KO > WT | nuclear factor I/A |
| 1421636_at | 37.8 | 120.8 | 1.68 | 3.2 | KO > WT | TBC1 domain family, member 8B |
| 1422142_at | 141.5 | 365.9 | 1.37 | 2.6 | KO > WT | nephrosis 1 homolog, nephrin (human) |
| 1422651_at | 13.8 | 255.5 | 4.21 | 19 | KO > WT | adiponectin, C1Q and collagen domain containing |
| 1423420_at | 25 | 64.8 | 1.37 | 2.6 | KO > WT | adrenergic receptor, beta 1 |
| 1424101_at | 503.7 | 1278.3 | 1.34 | 2.5 | KO > WT | heterogeneous nuclear ribonucleoprotein L |
| 1425032_at | 653.3 | 1851.5 | 1.5 | 2.8 | KO > WT | androgen binding protein beta |
| 1428944_at | 421.4 | 1505.4 | 1.84 | 3.6 | KO > WT | ubiquitin-like modifier activating enzyme 6 |
| 1431638_at | 53.7 | 145.4 | 1.44 | 2.7 | KO > WT | RIKEN cDNA 4930592A05 gene |
| 1432372_a_at | 177.7 | 523.4 | 1.56 | 2.9 | KO > WT | sepiapterin reductase |
| 1433078_at | 9.7 | 81.7 | 3.07 | 8.4 | KO > WT | RIKEN cDNA 5830435N06 gene |
| 1434987_at | 175.1 | 819 | 2.23 | 4.7 | KO > WT | aldehyde dehydrogenase 2, mitochondrial |
| 1434988_x_at | 204.5 | 647.5 | 1.66 | 3.2 | KO > WT | aldehyde dehydrogenase 2, mitochondrial |
| 1435679_at | 265.9 | 673.9 | 1.34 | 2.5 | KO > WT | optineurin |
| 1438120_x_at | 728.3 | 1907.3 | 1.39 | 2.6 | KO > WT | interleukin-1 receptor-associated kinase 1 |
| 1438219_at | 87.9 | 325.6 | 1.89 | 3.7 | KO > WT | similar to hCG45299; purine rich element binding protein A |
| 1438309_at | 209.5 | 613 | 1.55 | 2.9 | KO > WT | activin A receptor, type IC |
| 1438562_a_at | 1250 | 3547.9 | 1.51 | 2.8 | KO > WT | protein tyrosine phosphatase, non-receptor type 2 |
| 1439224_at | 187.2 | 485.4 | 1.37 | 2.6 | KO > WT | ankyrin repeat and IBR domain containing 1 |
| 1439260_a_at | 494.3 | 1256.2 | 1.35 | 2.5 | KO > WT | ectonucleotide pyrophosphatase/phosphodiesterase 3 |
| 1439263_at | 63.6 | 163.1 | 1.36 | 2.6 | KO > WT | hypothetical LOC14210 |
| 1441830_x_at | 10.9 | 69.3 | 2.67 | 6.4 | KO > WT | A kinase (PRKA) anchor protein 10 |
| 1446291_at | 25.9 | 70.1 | 1.44 | 2.7 | KO > WT | RIKEN cDNA 9330175H22 gene |
| 1447996_at | 548.2 | 1532.2 | 1.48 | 2.8 | KO > WT | expressed sequence AI848149 |
| 1448068_at | 120.3 | 331.6 | 1.46 | 2.8 | KO > WT | sterol O-acyltransferase 1 |
| 1448503_at | 9654.6 | 24560 | 1.35 | 2.5 | KO > WT | similar to myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1 |
| 1448761_a_at | 438.7 | 1188.7 | 1.44 | 2.7 | KO > WT | coatomer protein complex, subunit gamma 2 |
| 1449114_at | 77.5 | 194.4 | 1.33 | 2.5 | KO > WT | serine/threonine kinase 3 (Ste20, yeast homolog) |
| 1449434_at | 233.9 | 1278.2 | 2.45 | 5.5 | KO > WT | carbonic anhydrase 3 |
| 1449681_at | 170.2 | 483 | 1.5 | 2.8 | KO > WT | hepatoma-derived growth factor |
| 1450232_at | 26.9 | 82.6 | 1.62 | 3.1 | KO > WT | X-linked inhibitor of apoptosis |
| 1451285_at | 905.5 | 2620.4 | 1.53 | 2.9 | KO > WT | fusion, derived from t(12;16) malignant liposarcoma (human) |
| 1452124_at | 1915.1 | 5358.9 | 1.48 | 2.8 | KO > WT | ankyrin 3, epithelial |
| 1454278_at | 209.1 | 545.3 | 1.38 | 2.6 | KO > WT | RIKEN cDNA A430105D02 gene |
| 1454634_at | 64.1 | 194.1 | 1.6 | 3 | KO > WT | fucokinase |
| 1455381_at | 210.2 | 965.8 | 2.2 | 4.6 | KO > WT | hypothetical protein LOC100045622; RIKEN cDNA 4921513D23 gene |
| 1456505_at | 1089.1 | 3046.2 | 1.48 | 2.8 | KO > WT | Braf transforming gene |
| 1456843_at | 133 | 518.9 | 1.96 | 3.9 | KO > WT | Yamaguchi sarcoma viral (v-yes) oncogene homolog 1 |
| 1456961_at | 117.9 | 302.4 | 1.36 | 2.6 | KO > WT | enhancer of yellow 2 homolog (Drosophila); predicted gene 16373 |
| 1459882_at | 52.3 | 143.9 | 1.46 | 2.8 | KO > WT | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) |
| 1425191_at | 210.2 | 79.1 | −1.41 | 2.7 | WT > KO | occludin/ELL domain containing 1 |
| 1443220_at | 315.3 | 81.1 | −1.96 | 3.9 | WT > KO | reticulon 3 |
| 1442846_at | 572.3 | 142.7 | −2 | 4 | WT > KO | pre B-cell leukemia transcription factor 1; region containing RIKEN cDNA 2310056B04 gene; pre B-cell leukemia transcription factor 1 |
| 1459309_at | 45.4 | 17.3 | −1.39 | 2.6 | WT > KO | RUN and FYVE domain containing 3 |
| 1455956_x_at | 189.3 | 72.6 | −1.38 | 2.6 | WT > KO | cyclin D2 |
| 1443077_at | 401.9 | 121.9 | −1.72 | 3.3 | WT > KO | hypothetical protein LOC100043982; RIKEN cDNA 1700081L11 gene |
| 1432134_at | 56 | 1.3 | −5.43 | 43 | WT > KO | methyltransferase like 4, pseudogene 1 |
| 1446196_at | 34.7 | 9.4 | −1.88 | 3.7 | WT > KO | predicted gene 7996; high mobility group AT-hook 2 |
| 1434497_at | 166.2 | 59.1 | −1.49 | 2.8 | WT > KO | RIKEN cDNA 4933431E20 gene |
| 1446149_at | 260.6 | 73.2 | −1.83 | 3.6 | WT > KO | protein phosphatase 3, catalytic subunit, beta isoform |
| 1435061_at | 705.3 | 234.1 | −1.59 | 3 | WT > KO | nudix (nucleoside diphosphate linked moiety X)-type motif 11; nudix (nucleoside diphosphate linked moiety X)-type motif 10 |
| 1427217_at | 69 | 25.9 | −1.41 | 2.7 | WT > KO | zinc finger protein 455 |
| 1435415_x_at | 117.5 | 36.3 | −1.69 | 3.2 | WT > KO | MARCKS-like 1; predicted gene 9106 |
| 1441724_at | 283.7 | 113.3 | −1.32 | 2.5 | WT > KO | stromal antigen 1 |
| 1459398_at | 231.8 | 88.3 | −1.39 | 2.6 | WT > KO | pellino 1 |
| 1433288_at | 76.7 | 18.7 | −2.04 | 4.1 | WT > KO | RIKEN cDNA 1520401O13 gene |
| 1435831_at | 1969 | 408.8 | −2.27 | 4.8 | WT > KO | uroplakin 1B |
| 1455464_x_at | 1735.9 | 415.6 | −2.06 | 4.2 | WT > KO | uroplakin 1B |
| 1428492_at | 155.5 | 46.1 | −1.75 | 3.4 | WT > KO | GLI pathogenesis-related 2 |
| 1433944_at | 111.9 | 40.4 | −1.47 | 2.8 | WT > KO | HECT domain containing 2 |
| 1457348_at | 1313.1 | 421.5 | −1.64 | 3.1 | WT > KO | ADP-ribosylation factor 4 |
| 1440314_at | 474.4 | 187.7 | −1.34 | 2.5 | WT > KO | thyroid hormone receptor interactor 12 |
| 1444125_at | 434.2 | 61.7 | −2.82 | 7 | WT > KO | BEN domain containing 6 |
| 1455164_at | 560 | 100.1 | −2.48 | 5.6 | WT > KO | CDC42 GTPase-activating protein |
| 1450849_at | 7353.3 | 2719.9 | −1.43 | 2.7 | WT > KO | heterogeneous nuclear ribonucleoprotein U |
| 1456834_at | 102.5 | 37.2 | −1.46 | 2.8 | WT > KO | ring finger protein 144B |
| 1450457_at | 282.9 | 78.7 | −1.85 | 3.6 | WT > KO | similar to Casitas B-lineage lymphoma; Casitas B-lineage lymphoma |
| 1444951_at | 552.5 | 192.7 | −1.52 | 2.9 | WT > KO | DENN/MADD domain containing 1B |
| 1456078_x_at | 267 | 84.4 | −1.66 | 3.2 | WT > KO | tubulin, beta 2c, psuedogene 1; tubulin, beta 2C; tubulin, beta 2c, pseudogene 2 |
| 1458666_at | 200 | 45.5 | −2.14 | 4.4 | WT > KO | Rho GTPase activating protein 1; predicted gene 8514 |
| 1417055_at | 4404.3 | 1187.6 | −1.89 | 3.7 | WT > KO | RIKEN cDNA 0610009D07 gene |
| 1455986_at | 73 | 19.4 | −1.91 | 3.8 | WT > KO | zinc finger, DHHC domain containing 17 |
| 1460066_at | 993.6 | 310.5 | −1.68 | 3.2 | WT > KO | expressed sequence C80889 |
| 1434730_at | 122 | 47.3 | −1.37 | 2.6 | WT > KO | expressed sequence AI854517 |
| 1452284_at | 155.3 | 54.9 | −1.5 | 2.8 | WT > KO | protein tyrosine phosphatase, receptor type Z, polypeptide 1 |
| 1460336_at | 635.5 | 136.9 | −2.21 | 4.6 | WT > KO | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
| 1439902_at | 66.5 | 4 | −4.06 | 17 | WT > KO | complement component 5a receptor 1 |
| 1444692_at | 98.9 | 22.4 | −2.14 | 4.4 | WT > KO | EST AI316844 |
| 1457618_at | 337.2 | 109.6 | −1.62 | 3.1 | WT > KO | DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 |
| 1452027_a_at | 129.4 | 46.1 | −1.49 | 2.8 | WT > KO | transformation related protein 63 |
| 1430464_at | 131.5 | 32.3 | −2.03 | 4.1 | WT > KO | RIKEN cDNA 9430021M05 gene |
| 1430472_at | 36.1 | 5.1 | −2.82 | 7.1 | WT > KO | armadillo repeat containing 1 |
| 1442918_at | 190.5 | 46.5 | −2.03 | 4.1 | WT > KO | neuron navigator 3 |
| 1424051_at | 471.4 | 178.8 | −1.4 | 2.6 | WT > KO | collagen, type IV, alpha 2 |
| 1460427_a_at | 261.3 | 103.7 | −1.33 | 2.5 | WT > KO | a disintegrin and metallopeptidase domain 28 |
| 1436968_x_at | 990.6 | 381.6 | −1.38 | 2.6 | WT > KO | kelch-like 24 (Drosophila) |
| 1457343_at | 315.3 | 102.7 | −1.62 | 3.1 | WT > KO | adaptor-related protein complex AP-4, sigma 1 |
| 1447402_at | 168.9 | 58.1 | −1.54 | 2.9 | WT > KO | ataxin 1 |
| 1445066_at | 121.8 | 29.8 | −2.03 | 4.1 | WT > KO | tetratricopeptide repeat domain 7B |
| 1441579_at | 36 | 6.1 | −2.56 | 5.9 | WT > KO | doublesex and mab-3 related transcription factor like family A1 |
| 1435529_at | 217.8 | 75.3 | −1.53 | 2.9 | WT > KO | predicted gene 14446 |
| 1437311_at | 1432.7 | 504.2 | −1.51 | 2.8 | WT > KO | small nucleolar RNA host gene 11 (non-protein coding) |
| 1449318_at | 181.9 | 50.7 | −1.84 | 3.6 | WT > KO | similar to Tubulin, gamma 2; tubulin, gamma 2 |
| 1436981_a_at | 9813.1 | 2978.1 | −1.72 | 3.3 | WT > KO | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; predicted gene 4202 |
| 1448359_a_at | 161.8 | 63 | −1.36 | 2.6 | WT > KO | HIG1 domain family, member 1A |
| 1458700_at | 170.8 | 60.9 | −1.49 | 2.8 | WT > KO | leucine rich repeat containing 8 family, member C |
| 1447905_x_at | 2642.3 | 1006.4 | −1.39 | 2.6 | WT > KO | nucleoporin 62 |
| 1442867_at | 335.6 | 97.1 | −1.79 | 3.5 | WT > KO | multiple EGF-like-domains 11 |
| 1421868_a_at | 146.1 | 56.3 | −1.38 | 2.6 | WT > KO | pancreatic lipase |
| 1443441_x_at | 110.9 | 42.9 | −1.37 | 2.6 | WT > KO | predicted gene 5141 |
| 1439847_s_at | 149.5 | 41.9 | −1.84 | 3.6 | WT > KO | Kruppel-like factor 12 |
| 1441764_at | 144.8 | 57 | −1.35 | 2.5 | WT > KO | PR domain containing 10 |
| 1459104_at | 175.5 | 69.6 | −1.33 | 2.5 | WT > KO | budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) |
| 1446736_at | 184.9 | 62.2 | −1.57 | 3 | WT > KO | MyoD family inhibitor domain containing |
| 1440716_at | 106.7 | 28.3 | −1.91 | 3.8 | WT > KO | RIKEN cDNA 6430604M11 gene |
| 1453593_at | 183.5 | 70.2 | −1.39 | 2.6 | WT > KO | vestigial like 3 (Drosophila) |
| 1446421_at | 151.7 | 57.6 | −1.4 | 2.6 | WT > KO | schwannomin interacting protein 1 |
| 1433183_at | 24.9 | 1.5 | −4.05 | 17 | WT > KO | RIKEN cDNA 6720477C19 gene |
| 1426095_a_at | 270.4 | 103 | −1.39 | 2.6 | WT > KO | tumor necrosis factor receptor superfamily, member 22 |
| 1431079_at | 172.2 | 64.3 | −1.42 | 2.7 | WT > KO | C1q and tumor necrosis factor related protein 2 |
| 1424507_at | 77 | 21.1 | −1.87 | 3.6 | WT > KO | Ras and Rab interactor 1 |
| 1421603_a_at | 395.1 | 106.3 | −1.89 | 3.7 | WT > KO | carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 2 |
| 1451870_a_at | 117.7 | 40.1 | −1.55 | 2.9 | WT > KO | bromodomain containing 4 |
| 1431306_at | 97.5 | 13.4 | −2.86 | 7.3 | WT > KO | 5′-nucleotidase, cytosolic III |
| 1436713_s_at | 78.8 | 26.6 | −1.57 | 3 | WT > KO | maternally expressed 3 |
| 1441701_at | 326.4 | 107.2 | −1.61 | 3 | WT > KO | zinc finger protein 148 |
| 1443447_at | 133.9 | 52.5 | −1.35 | 2.6 | WT > KO | 5-azacytidine induced gene 2 |
| 1453371_at | 438.4 | 174.5 | −1.33 | 2.5 | WT > KO | regulation of nuclear pre-mRNA domain containing 2 |
| 1429882_at | 1621.2 | 632.3 | −1.36 | 2.6 | WT > KO | RIKEN cDNA 6820431F20 gene |
| 1445530_at | 46.1 | 2.9 | −3.99 | 16 | WT > KO | transmembrane protein 194B |
| 1444279_at | 668.1 | 229.4 | −1.54 | 2.9 | WT > KO | HECT, UBA and WWE domain containing 1 |
| 1458832_at | 176 | 68.7 | −1.36 | 2.6 | WT > KO | growth hormone receptor |
| 1452517_at | 1086.2 | 369.7 | −1.55 | 2.9 | WT > KO | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 |
| 1425847_a_at | 148.2 | 51.1 | −1.54 | 2.9 | WT > KO | RIKEN cDNA B230120H23 gene |
| 1438662_at | 93.1 | 20.9 | −2.16 | 4.5 | WT > KO | adherens junction associated protein 1 |
| 1425934_a_at | 671.3 | 128.8 | −2.38 | 5.2 | WT > KO | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 |
| 1422140_at | 163 | 46.2 | −1.82 | 3.5 | WT > KO | similar to putative G-protein coupled receptor; predicted gene 2635; component of Sp100-rs; predicted gene 2666; predicted gene 7582; predicted gene 7592; predicted gene 7609 |
| 1443239_at | 138.6 | 47 | −1.56 | 2.9 | WT > KO | microtubule-associated protein 2 |
| 1421916_at | 381 | 144 | −1.4 | 2.6 | WT > KO | platelet derived growth factor receptor, alpha polypeptide |
| 1419971_s_at | 4010.9 | 1451.2 | −1.47 | 2.8 | WT > KO | solute carrier family 35, member A5 |
| 1419972_at | 434.2 | 98 | −2.15 | 4.4 | WT > KO | solute carrier family 35, member A5 |
| 1448346_at | 3281.1 | 1193.2 | −1.46 | 2.7 | WT > KO | cofilin 1, non-muscle; similar to Cofilin-1 (Cofilin, non-muscle isoform); predicted gene 6180 |
| 1419021_at | 55.1 | 4.5 | −3.61 | 12 | WT > KO | mcf.2 transforming sequence |
| 1434958_at | 95.8 | 35.5 | −1.43 | 2.7 | WT > KO | sacsin |
| 1433382_at | 217.5 | 77.5 | −1.49 | 2.8 | WT > KO | energy homeostasis associated |
| 1446512_at | 214 | 85.2 | −1.33 | 2.5 | WT > KO | predicted gene 5909; zinc finger CCCH-type containing 15 |
| 1432298_at | 196 | 68.6 | −1.51 | 2.9 | WT > KO | RIKEN cDNA 4921508M14 gene |
| 1446095_at | 217.3 | 53.9 | −2.01 | 4 | WT > KO | antisense Igf2r RNA |
| 1445453_at | 270.3 | 91 | −1.57 | 3 | WT > KO | helicase with zinc finger domain |
| 1452494_s_at | 75.6 | 29.5 | −1.36 | 2.6 | WT > KO | solute carrier organic anion transporter family, member 1b2 |
| 1442833_at | 837.4 | 144.8 | −2.53 | 5.8 | WT > KO | DNA segment, Chr 15, ERATO Doi 30, expressed |
| 1447049_at | 112.7 | 34.8 | −1.7 | 3.2 | WT > KO | IQ motif and WD repeats 1 |
| 1441283_at | 325.7 | 112 | −1.54 | 2.9 | WT > KO | cyclin Y; similar to cyclin fold protein 1 |
| 1434067_at | 267.8 | 78.7 | −1.77 | 3.4 | WT > KO | expressed sequence AI662270 |
| 1434068_s_at | 290.4 | 49.6 | −2.55 | 5.9 | WT > KO | expressed sequence AI662270 |
| 1422313_a_at | 540.1 | 213.1 | −1.34 | 2.5 | WT > KO | insulin-like growth factor binding protein 5 |
| 1449405_at | 2035.8 | 731.6 | −1.48 | 2.8 | WT > KO | tensin 1 |
| 1425555_at | 164.7 | 45 | −1.87 | 3.7 | WT > KO | CDC2-related kinase, arginine/serine-rich |
| 1420073_s_at | 176.4 | 64.8 | −1.44 | 2.7 | WT > KO | gb:C78041 EST |
| 1443347_at | 99.8 | 37 | −1.43 | 2.7 | WT > KO | gb:BG063775 EST |
| 1444498_at | 147.3 | 52.9 | −1.48 | 2.8 | WT > KO | gb:BM116117 EST |
| 1444591_at | 316.8 | 71.1 | −2.16 | 4.5 | WT > KO | gb:AI429418 EST |
| 1445902_at | 139.1 | 40.7 | −1.77 | 3.4 | WT > KO | gb:BG076325 EST |
| 1457122_at | 342.7 | 122.1 | −1.49 | 2.8 | WT > KO | gb:BB209527 EST |
| 1458257_at | 109.4 | 40.7 | −1.43 | 2.7 | WT > KO | gb:BM196689 EST |