Fig. 6.

Lumican suppresses growth but not angiogenesis in 4T1 breast cancers. a Equal numbers of empty vector control and lumican overexpressing 4T1 breast cancer cells were orthotopically injected in triplicate into the fat-pad of syngenic mice. Tumors were evident after 7 days and tumor volume was measured every other day for 14 days. Tumor volume is depicted as average fold increase (+/− SE) of three independent experiments compared to control tumors on day 7. b representative pictures of tumors dissected from a single experiment. c Final mass of dissected tumors was compared and is depicted as the average decrease (+/− SE) of three independent experiments compared to final control tumor mass. * indicates p < .05, student’s t-test. d Dissected tumors were sectioned and vascular density was monitored by immunohistochemistry with anti-CD31 antibodies. e Densitometry by Image J software was used to quantify CD31 staining in tumor sections