Fig. 6.
Diastolic and β-adrenergic deficiency in Tg fb1−/− hearts. Isolated, work-performing hearts from adult Tg fb1−/− Scid mice (A). β-Adrenergic-stimulated contractility (+dP/dt) and relaxation (−dP/dt) rates in LFA-1 antibody-treated adult Tg fb1−/− mice. Immunodeficiency (Scid) or immunosuppression (LFA-1 antibody treatment) is required to circumvent weaning age lethality (see Section 3.2 for explanation). IVP: interventricular pressure.