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. Author manuscript; available in PMC: 2014 Oct 24.
Published in final edited form as: Cell. 2013 Oct 24;155(3):10.1016/j.cell.2013.09.023. doi: 10.1016/j.cell.2013.09.023

Figure 6. Nucleocytoplasmic shuttling dynamics are altered for the LCCS1 FinMajor disease protein.

Figure 6

(A–B) FinMajor has altered nuclear shuttling activity. (A) FRAP analysis of HeLa cells expressing GFP-hGLE1B and GFP-FinMajor. (B) FRAP analysis of hGLE1 siRNA-treated HeLa cells expressing siRNA-resistant GFP-hGle1BR or GFP-FinMajorR. Bar, 10µm. (C–D) Recovery curves of the experimentally determined bleached region, fit with a one-phase association model. Error bars represent mean ± 95% CI with n ≥ 12 cells from 3 independent experiments.