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Polarized curvatures as binding indicators of protein surfaces. Maximal curvature (κ1), minimal curvature (κ2), positive electrostatic surface potential (Φ+) and negative electrostatic surface potential (Φ−) are combined to indicate potential binding sites.
| κ1 > 0 | κ2 < 0 | |
|---|---|---|
| Φ+ > 0 | site for negatively charged protein | site for negatively charged small ligand |
| Φ− < 0 | site for positively charged protein | site for positively charged small ligand |
