Immunoblot analysis of SMAD3 expression in liver cytosol from CFTRΔF508 mice. Cytosol (200 mg) prepared from livers of female CFTRΔF508 of each genotype (+/+, +/−, −/−) was resolved in a 12% SDS-polyacrylamide gel, electrotransferred to nitrocellulose membranes, immunoblotted with a rabbit anti-SMAD3 antibody (Calbiochem) and developed with the Pierce West Pico ECL substrate. Panel A shows the immunoreactivity of SMAD3 from two each female CFTRΔF508(+/+, +/−, −/−) mice. Panel B shows the levels of SMAD3 and SULT1E1 activity in liver cytosols of different genotype CFTRΔF508 mice.