Table 2.
SULT1E1 activity in CFTRAF508 mouse tissues. Cytosol was prepared from different mouse tissues and assayed for SULT1E1 activity as described previously [14]. Results are expressed as pmol sulfated product/mg protein/min. ND means that there was no detectable activity.
| Tissue | ĘF508(+/+) Female | ĘF508(+/−) Female | ĘF508(−/−) Female | ĘF508(+/+) Male | ĘF508(+/−) Male | ĘF508(−/−) Male |
|---|---|---|---|---|---|---|
| Liver | 0.28 ± 0.10 | 0.15 ± 0.13 | 20.80 ± 10.4 | 0.24 ± 0.18 | 0.15 ± 0.15 | 13.05 ± 9.1 |
| Lung | 0.11 ± 0.03 | 0.14 ± 0.02 | 0.13 ± 0.04 | 0.11 ± 0.04 | 0.15 ± 0.03 | 0.12 ± 0.04 |
| Endometrium | 0.28 ± 005 | 0.29 ± 0.03 | 0.27 ± 0.05 | – | – | – |
| Testis | – | – | – | 26 ± 3 | 25 ± 7 | 27 ± 5 |
| Intestine | ND | ND | ND | ND | ND | ND |
| Colon | ND | ND | ND | ND | ND | ND |
| Kidney | ND | ND | ND | ND | ND | ND |
| Spleen | ND | ND | ND | ND | ND | ND |