Table 5.
Selected genes associated with cholesterol metabolism with altered expression in CFTR-siRNA-MMNK-1 cells.
| Gene ST probe set | Mk cont Ave | Mk siRNA Ave | Gene symbol | mRNA Description | p-value | Regulation |
|---|---|---|---|---|---|---|
| 7945831 | 195 | 154 | OSBPL5 | Oxysterol binding protein-like 5 | 0.02 | Down |
| 7950067 | 2025 | 1435 | DHCR7 | 7-Dehydrocholesterol reductase | 0.03 | Down |
| 7913462 | 4326 | 3431 | DCHR24 | 24-Dehydrocholesterol reductase | 0.003 | Down |