Fig. 1.
(a) Body weight, (b) blood glucose and (c) HbA1c measurements for wild-type, db/db and dbM mice. db/db and dbM mice had significantly increased body weight compared with wild-type mice (wild-type 21.88 ± 0.371 g; db/db 52.36 ± 1.207 g; dbM 51.44 ± 1.013 g; p < 0.0001). Blood glucose was significantly increased in db/db and dbM mice (wild-type 5.899 ± 0.296 mmol/l; db/db 27.76 ± 0.625 mmol/l; dbM 22.05 ± 2.009 mmol/l; p < 0.0001), as were HbA1c values (wild-type 20.06 ± 0.400 mmol/mol; db/db 56.57 ± 2.543 mmol/mol; dbM 45.00 ± 2.400 mmol/mol; p < 0.0001). Diabetic db/db and dbM mice had similar body weight (p > 0.999), but dbM mice had significantly decreased blood glucose (p < 0.001) and HbA1c values (p < 0.001). **p < 0.001, ****p < 0.0001. To convert values for HbA1c in mmol/mol into %, multiply by 0.09148 and add 2.152, or use the conversion calculator at www.hba1c.nu/eng/