Table 2.
Top five molecular and cellular functions associated with proteins upregulated in diabetic retina
| Category and annotations | p value | Molecules | No. molecules |
|---|---|---|---|
| Cell death and survival | |||
| Recovery of retinal rods | 1.17 × 10−6 | ABCA4, RGS9BP | 2 |
| Delay in recovery of retinal rods | 1.11 × 10−3 | ABCA4 | 1 |
| Apoptosis of endothelial cell lines | 4.45 × 10−3 | CDH2 | 1 |
| Apoptosis of photoreceptors | 1.22 × 10−3 | ROM1 | 1 |
| Cellular compromise | |||
| Degeneration of photoreceptors | 1.07 × 10−3 | ABCA4, ROM1 | 2 |
| Neurodegeneration of photoreceptors | 6.67 × 10−3 | ROM1 | 1 |
| Degeneration of retinal rods | 1.33 × 10−2 | ROM1 | 1 |
| Amino acid metabolism | |||
| Transport of l-histidine | 1.11 × 10−3 | SLC38A3 | 1 |
| Transport of l-glutamine | 2.23 × 10−3 | SLC38A3 | 1 |
| Carbohydrate metabolism | |||
| Quantity of N-retinylidene-phosphatidylethanolamine | 1.11 × 10−3 | ABCA4 | 1 |
| Cell morphology | |||
| Size of rod outer segment disks | 1.11 × 10−3 | ROM1 | 1 |
| Abnormal morphology of photoreceptor outer segments | 1.12 × 10−3 | ABCA4, ROM1 | 2 |
| Blebbing of nucleus | 2.23 × 10−3 | LMNB1 | 1 |
| Length of rod outer segments | 4.45 × 10−3 | ROM1 | 1 |
| Abnormal morphology of rod outer segments | 1.55 × 10−2 | ROM1 | 1 |
| Innervation of muscle | 2.43 × 10−2 | LMNB1 | 1 |
| Abnormal morphology of photoreceptors | 3.73 × 10−2 | ABCA4 | 1 |
| Extension of axons | 4.16 × 10−2 | CDH2 | 1 |
Protein abbreviations are based on official gene symbols (NCBI Entrez Gene)