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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Gene Ther. 2013 Sep 19;20(12):1172–1177. doi: 10.1038/gt.2013.47

Figure 1. Gadoteridol increases the transduction efficiency of AAV1 but not AAV5.

Figure 1

(a) Representative sections illustrate the rostro-caudal extent of GFP expression in animals injected with rAAV1 (top panels) or AAV5 (bottom panels) co-infused with Lactated Ringer's solution (+Ringers) or gadoteridol (+Gd). Insets show magnification of dorsal area CA1. (b) Densitometry analysis of the injected hippocampal hemispheres. (c) Densitometry analysis of the contralateral uninjected hemisphere. Data represent the mean ± SEM (Gd/AAV1, n=3; ringers/rAAV1, n=3; Gd/AAV5, n=4; ringers/rAAV5, n=4). ***P<0.005, **P<0.005, *P<0.05. Significant indicators above histogram bars indicate comparison to Lactated Ringer's control. Scale bars = 1 mm.