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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Gene Ther. 2013 Sep 19;20(12):1172–1177. doi: 10.1038/gt.2013.47

Figure 2. Gadoteridol co-infusion with AAV1 does not result in changes in tropism or adverse effects on tissue health.

Figure 2

(a) Labeling with NeuN and GFAP reveals that gadoteridol co-infusion does not affect AAV1 neuronal tropism. Scale bar= 25 μm. Nissl staining indicates there is no obvious cell damage when Gd is co-infused with either AAV1 (b) or AAV5 (c) (Top panels). GFAP immunostaining shows no inflammation outside the needle track (middle panel). Only co-infusion of Gd with AAV5 resulted in an increase Iba I immunoreactivity, indicating microglial activation in the injected hippocampi (c, bottom panel). Scale bars= 1 mm. (insets show magnification of the area around the needle track).