Table 3.
Adjusted odds ratios (aORs) and 95% CIs for the relationship between individual organochlorine pesticides and endometriosis, Group Health, 1996–2001.
| Pesticide quartiles (pg/g serum) | All endometriosis | Ovarian endometriosis | ||
|---|---|---|---|---|
| Case/control (n) | aORa (95% CI) | Case/control (n) | aORa (95% CI) | |
| β-HCH | ||||
| ≤ 26.99 | 49/126 | 1.0 | 17/126 | 1.0 |
| > 26.99–43.06 | 41/127 | 0.8 (0.5, 1.4) | 21/127 | 1.2 (0.5, 2.4) |
| > 43.06–74.01 | 78/127 | 1.7 (1.0, 2.8) | 42/127 | 2.5 (1.2, 5.2) |
| > 74.01 | 64/127 | 1.3 (0.8, 2.4) | 42/127 | 2.5 (1.1, 5.3) |
| γ-HCHb | ||||
| ≤ 10.0 (LOD) | 129/295 | 1.0 | 69/295 | 1.0 |
| > 10.0–13.89 | 54/112 | 1.1 (0.8, 1.7) | 29/112 | 1.1 (0.7, 1.9) |
| > 13.89 | 61/112 | 1.3 (0.9, 1.9) | 32/112 | 1.2 (0.7, 2.0) |
| ∑HCH (mol/g serum)c | ||||
| ≤ 0.12 | 54/134 | 1.0 | 24/134 | 1.0 |
| > 0.12–0.18 | 48/135 | 0.8 (0.5, 1.3) | 21/135 | 0.8 (0.4, 1.7) |
| > 0.18–0.29 | 79/134 | 1.4 (0.9, 2.2) | 45/134 | 1.8 (1.0, 3.3) |
| > 0.29 | 67/135 | 1.1 (0.6, 1.8) | 42/135 | 1.6 (0.8, 3.0) |
| Heptachlor epoxide | ||||
| ≤ 17.10 | 40/110 | 1.0 | 21/110 | 1.0 |
| > 17.10–26.19 | 55/110 | 1.4 (0.8, 2.4) | 22/110 | 1.0 (0.5, 2.0) |
| > 26.19–42.91 | 59/110 | 1.4 (0.8, 2.3) | 34/110 | 1.3 (0.7, 2.6) |
| > 42.91 | 51/109 | 1.2 (0.7, 2.1) | 28/109 | 1.1 (0.5, 2.2) |
| Oxychlordane | ||||
| ≤ 28.31 | 52/124 | 1.0 | 24/124 | 1.0 |
| > 28.31–51.96 | 46/125 | 0.8 (0.5, 1.3) | 23/125 | 0.8 (0.4, 1.6) |
| > 51.96–79.55 | 57/126 | 1.0 (0.6, 1.6) | 34/126 | 1.2 (0.6, 2.4) |
| > 79.55 | 73/124 | 1.2 (0.7, 2.1) | 45/124 | 1.5 (0.8, 3.0) |
| trans-Nonachlor | ||||
| ≤ 51.37 | 55/134 | 1.0 | 21/134 | 1.0 |
| > 51.37–75.15 | 55/135 | 1.0 (0.6, 1.6) | 31/135 | 1.4 (0.7, 2.7) |
| > 75.15–107.65 | 56/134 | 1.0 (0.6, 1.6) | 33/134 | 1.3 (0.7, 2.6) |
| > 107.65 | 82/135 | 1.4 (0.8, 2.4) | 47/135 | 1.8 (0.9, 3.7) |
| ∑Chlordane (mol/g serum)c | ||||
| ≤ 0.21 | 53/134 | 1.0 | 23/134 | 1.0 |
| > 0.21–0.33 | 56/135 | 1.0 (0.6, 1.7) | 24/135 | 1.0 (0.5, 1.9) |
| > 0.33–0.52 | 57/134 | 1.1 (0.6, 1.8) | 36/134 | 1.5 (0.8, 2.9) |
| > 0.52 | 82/135 | 1.4 (0.8, 2.5) | 49/135 | 1.8 (0.9, 3.7) |
| p,p′-DDE | ||||
| ≤ 905.86 | 55/134 | 1.0 | 25/134 | 1.0 |
| > 905.86–1575.51 | 69/134 | 1.2 (0.8, 2.0) | 38/134 | 1.4 (0.8, 2.6) |
| > 1575.51–2816.55 | 62/134 | 1.1 (0.7, 1.7) | 31/134 | 1.1 (0.6, 2.1) |
| > 2816.55 | 61/135 | 1.0 (0.6, 1.7) | 37/135 | 1.2 (0.6, 2.4) |
| p,p′-DDT | ||||
| ≤ 18.79 | 58/128 | 1.0 | 21/128 | 1.0 |
| > 18.79–28.36 | 58/128 | 0.9 (0.6, 1.5) | 33/128 | 1.4 (0.7, 2.6) |
| > 28.36–44.38 | 55/128 | 0.8 (0.5, 1.4) | 32/128 | 1.2 (0.6, 2.3) |
| > 44.38 | 66/129 | 0.9 (0.6, 1.5) | 38/129 | 1.3 (0.7, 2.6) |
| ∑DDT (mol/g serum)c | ||||
| ≤ 2.88 | 55/135 | 1.0 | 25/135 | 1.0 |
| > 2.88–5.03 | 71/134 | 1.3 (0.8, 2.0) | 39/134 | 1.5 (0.8, 2.7) |
| > 5.03–8.95 | 59/135 | 1.0 (0.6, 1.7) | 29/135 | 1.1 (0.6, 2.1) |
| > 8.95 | 63/134 | 1.1 (0.6, 1.8) | 39/134 | 1.4 (0.7, 2.7) |
| Dieldrind | ||||
| ≤ 10.0 (LOD) | 59/151 | 1.0 | 32/151 | 1.0 |
| > 10.0–48.18 | 52/97 | 1.3 (0.8, 2.1) | 17/97 | 0.7 (0.4, 1.5) |
| > 48.18–73.74 | 65/123 | 1.1 (0.7, 1.8) | 39/123 | 1.2 (0.7, 2.1) |
| > 73.74 | 52/124 | 0.8 (0.5, 1.3) | 30/124 | 0.8 (0.4, 1.4) |
| Hexachlorobenzene | ||||
| ≤ 159.74 | 49/135 | 1.0 | 23/135 | 1.0 |
| > 159.74–278.998 | 71/134 | 1.4 (0.9, 2.1) | 40/134 | 1.6 (0.9, 3.0) |
| > 278.998–589.30 | 72/134 | 1.4 (0.9, 2.1) | 35/134 | 1.4 (0.7, 2.6) |
| > 589.30 | 56/135 | 0.9 (0.6, 1.5) | 34/135 | 1.1 (0.6, 2.1) |
| Mirexb | ||||
| ≤ 10.0 (LOD) | 133/320 | 1.0 | 68/320 | 1.0 |
| > 10.0–15.47 | 45/97 | 1.1 (0.7, 1.8) | 28/97 | 1.3 (0.8, 2.2) |
| > 15.47 | 60/98 | 1.5 (1.0, 2.2) | 29/98 | 1.2 (0.7, 2.1) |
| aAdjusted for age, reference date year, smoking, alcohol, education, natural logarithm-transformed total lipids, and race/ethnicity. bLowest category consists of values < LOD. Middle and top categories, ≤ median or > median, based on observations with values among controls. cSummed chemicals used multiple imputation data (five data sets); quartile cut points and frequencies are from first imputed data set. dAll samples with values < LOD were categorized in the lowest category. Subsequent categories were created using the 50th and 75th percentile among the distribution in controls. | ||||