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. 2013 Dec 5;8(12):e83317. doi: 10.1371/journal.pone.0083317

Figure 3. Systemic and renal haemodynamics during UT antagonism.

Figure 3

Effect of UT antagonist SB-706375 (0.01 mg. kg-1. min-1, solid bars, WKY n = 6, SHR n = 8) or vehicle (0.154 mol/L NaCl, open bars, n = 5 per strain) infusion on mean arterial pressure (A-B), effective renal blood flow (C-D) and glomerular filtration rate (E-F) in anaesthetised 4-5 week-old WKY rats (left column) and pre-hypertensive SHRs (right column). Data shown are mean ± SEM for the baseline control period and the final 15 mins of the treatment period when effects were maximal. ** P < 0.01, *** P < 0.001 compared with vehicle-treated rats, Sidak’s test.