Skip to main content
. 2013 Dec 5;8(12):e83317. doi: 10.1371/journal.pone.0083317

Figure 4. Renal water and sodium handling during UT antagonism.

Figure 4

Effect of UT antagonist SB-706375 (0.01 mg. kg-1. min-1, solid bars, WKY n = 6, SHR n = 8) or vehicle (0.154 mol/L NaCl, open bars, n = 5 per strain) infusion on urine flow rate (A-B), sodium excretion rate (C-D) and fractional sodium excretion (E-F) in anaesthetised 4-5 week-old WKY rats (left column) and pre-hypertensive SHRs (right column). Data shown are mean ± SEM for the baseline control period and the final 15 mins of the treatment period when effects were maximal. * P <0.05, ** P < 0.01, *** P < 0.001 compared with vehicle-treated rats, Sidak’s test.