Table 3. Baseline measurements taken during control 0.154 mol/L NaCl infusion before UT antagonist infusion in anaesthetised 4-5 week-old SHR and WKY rats.
| Parameter |
WKY
|
SHR
|
P value | ||
|---|---|---|---|---|---|
| Vehicle | UT antagonist | Vehicle | UT antagonist | ||
| (n = 5) | (n = 6) | (n = 5) | (n = 8) | ||
| MAP (mmHg) | 90 ± 8 | 76 ± 5 | 92 ± 2 | 100 ± 7 | 0.059 |
| ERBF (ml. min-1. 100 g bwt-1) | 5.8 ± 0.8 | 5.8 ± 0.9 | 6.1 ± 1.0 | 6.3 ± 0.4 | NS |
| GFR (ml. min-1. 100 g bwt-1) | 0.6 ± 0.1 | 0.5 ± 0.1 | 0.6 ± 0.1 | 0.5 ± 0.1 | NS |
| UV (μl. min-1. 100 g bwt-1) | 29.3 ± 4.5 | 21.7 ± 5.3 | 26.1 ± 8.1 | 13.8 ± 2.7 | NS |
| UNaV (μmol. min-1. 100 g bwt-1) | 5.0 ± 0.8 | 3.9 ± 1.0 | 2.7 ± 0.8 | 1.7 ± 0.3 | <0.01 |
| FENa (%) | 7.8 ± 0.9 | 8.2 ± 1.6 | 3.9 ± 1.3 | 4.8 ± 0.4 | <0.05 |
Data shown are mean ± SEM
MAP: mean arterial pressure, ERBF: effective renal blood flow, GFR: glomerular filtration rate, UV: urine flow rate, UNaV: sodium excretion rate, FENa: fractional sodium excretion, NS: not significant.