Table 1. Anatomopathological analysis of brain, spinal cord and sciatic nerve from nude mice treated with STX140 or paclitaxel.

Agent	mg/kg	Route	Schedule	Mortality	Neurotoxic
none	-	-	-	No	No
paclitaxel	30	iv	qod ×5	No	Yes
STX140	35	po	qd ×10	Yes	No
STX140	30	po	qd ×7	Yes	No
STX140	25	po	qd ×11	No	No
STX140	20	po	qd ×24	No	No
STX140	10	po	qd ×28	No	No