Table 3. Multivariate Cox regression analysis of potential prognostic factors for ovarian cancer.
| Parameter* | Hazard ratio† | 95% confidence interval | p value |
|---|---|---|---|
| Age > 59.1 years | 0.991 | 0.939-1.045 | 0.731 |
| BMI > 23.2 | 0.987 | 0.880-1.108 | 0.830 |
| Existence of ascites | 0.991 | 0.472-1.819 | 0.824 |
| Existence of peritoneal metastasis | 2.248 | 1.126-5.629 | 0.002§ |
| Existence of lymphatic metastasis | 1.226 | 0.607-2.477 | 0.570 |
| Size of residual site >2 cm | 3.073 | 1.240-7.223 | <0.001§ |
| Stage | 0.004§ | ||
| III | 2.556 | 1.128-9.036 | |
| IV | 5.936 | 1.057-16.078 | |
| Histotype | 0.016§ | ||
| Mucinous | 1.073 | 1.075-3.969 | |
| Endometrioid | 0.750 | 1.571-5.394 | |
| Clear cell | 1.055 | 1.334-7.881 | |
| Undifferentiated | 2.345 | 1.450-12.216 | |
| Grade | 0.015§ | ||
| G2 | 1.901 | 1.445-7.827 | |
| G3 | 2.381 | 1.785-9.788 | |
| Density of CD68+COX-2+ TAMs > 10.4 mm-2 | 1.010 | 1.006-1.035 | 0.042§ |
| Density of CD68-COX-2+ cancer cells > 239.4 mm-2 | 1.006 | 1.002-1.009 | 0.002§ |
| TAM M1/M2 ratio ≤ 2.4 | 1.767 | 1.061-6.957 | 0.019§ |
| MUC2-immunostaining ++/+++ | 2.354 | 1.031-10.707 | 0.005§ |
* To be concise, the reference groups (hazard ratio=1) for each parameter were omitted. These groups were “Age ≤ 59.1 years”, “BMI ≤ 23.2”, “No ascites”, “No peritoneal metastasis”, “No lymphatic metastasis”, “Size of residual site ≤ 2 cm”, “Stage II’, “Serous”, “G1”, “Density of CD68+COX-2+ TAMs ≤ 10.4 mm-2”, “Density of CD68-COX-2+ cancer cells ≤ 239.4 mm-2”, “TAM M1/M2 ratio > 2.4” and “MUC2-immunostaining -/+”, respectively. All the patients accepted a standard taxol + platinum therapy, therefore, the chemotherapy scenario was not included as a parameter for the multivariate analysis.
† The hazard ratio was defined as the rate of patient death in the target group divided by the rate of patient death in the reference group during the 5-year follow-up.
§ Statistical significance.