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. 2013 Dec 6;8(12):e80337. doi: 10.1371/journal.pone.0080337

Table 5. HIF-1α and HIF-2α expression and clinicopathological features for colorectal cancer.

Heterogeneity
Clinicopathological features Nuber of studies Nuber of patients Pooled OR (95%CI) P value I2(%) P value Model used
HIF-1α
Differentiation grade 15 2226 0.97 (0.67–1.39) 0.864 39.2 0.06 REM
Dukes' stages 5 408 0.39(0.17–0.89) 0.025 66.2 0.019 REM
Lymphnode status 15 1490 0.49(0.32–0.73) 0.001 62.4 0.001 REM
Metastasis 5 480 0.29(0.11–0.81) 0.018 52.8 0.076 REM
UICC stage 9 1733 0.42(0.3–0.59) 0.000 53.2 0.029 REM
Depth of invasion 9 1016 0.71(0.51–0.99) 0.045 0.00 0.851 FEM
HIF-2α
Differentiation grade 2 782 0.484(0.289–0.812) 0.006 58 0.123 FEM
Dukes' stages 2 177 0.9(0.197–4.168) 0.9 82 0.019 REM
Lymphnode status 3 329 0.95(0.418–2.16) 0.904 63.7 0.064 REM
Depth of invasion 2 177 0.379(0.038–3.798) 0.409 83.4 0.014 REM

REM, random-effects model; FEM, fixed-effects model; OR, odds ratio; CI, confidence interval.