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. 2013 Dec 6;8(12):e82112. doi: 10.1371/journal.pone.0082112

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© 2013 Luo et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The effect of Mdivi-1 on migration of mt-SOD1^G93A-Dendra expressed in normal muscle fibers.

(A) Migration in the presence of Mdivi-1; (B). Migration in DMSO as a control. (C) The migration time course of mt-SOD1^G93A-Dendra. Solid lines are the linear regression of the data after 2 minutes of the photoactivation. Dashed lines are the linear regression of the data in the first 2 minutes. The migration rates are listed in Table 1 . (P<0.01). Note, Mdivi-1 closely restored the migration rate of mutant mt-SOD1^G93A-Dendra. (D) Western blot analysis of Mfn1, Mfn2 and Drp1 in skeletal muscle of G93A and control (ctrl) mice. There are no significant changes in expression level of these mitochondrial fusion/fission proteins in G93A muscle at the age of 2 month. (n=5 mice for control and G93A respectively).