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. 2013 Dec 6;8(12):e82407. doi: 10.1371/journal.pone.0082407

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© 2013 Thamm et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Alignments were performed with BioEdit (version 7.0.5) by using the core amino-acid sequences lacking the variable regions of the N- and C-terminus and the third cytoplasmic loop. Maximum parsimony analysis was calculated with MEGA4. The receptor sequences followed by their accession numbers are listed in the order illustrated: Homo sapiens (Hs5-HT_1B, acc. no. NP_000854), Danio rerio (Dr5-HT_1B, AAI63698), Hs5-HT_1D (NP_000855), Hs5-HT_1E (NP_000856), Hs5-HT_1F (NP_000857), Dr5-HT_1F (NP_001076425), Hs5-HT_1A (NP_000515), Dr5-HT_1A (NP_001139238), Aplysia californica (Ac5-HT₁, AAM46088, AAC28786), Panulirus interruptus (Pi5-HT₁, AY528822), Apis mellifera (Am5-HT₁, CBI75449), Drosophila melanogaster (Dm5-HT_1A, CAA77570), Dm5-HT_1B (CAA77571), Hs5-HT_5A (NP_076917), Dr5-HT_5A, (NP_001119882), Am5-HT₇ (AM076717), Dm5-HT₇ (NP_524599), Aplysia kurodai (Ak5-HT₇, ACQ90247), Hs5-HT_7A (NP_000863), Hs5-HT_7D (NP_062873), Hs5-HT_7B (NP_062874), Hs5-HT₄ (NP_001035259), Ac5-HT₂ (Q16951), Ac5-HT₁ (Q16950), Hs5-HT₆ (NP_000862), Hs5-HT_2B (NP_000858), Dr5-HT_2B (ABI18978), Hs5-HT_2A (NP_000612), Dr5-HT_2A (CAQ15355), Hs5-HT_2C (NP_000859), Dr5-HT_2C (CAX14715), Am5-HT_2β (FR727108), Dm5-HT_2β (NM_141548/NM_169229), Pi5-HT_2β (AY550910), Am5-HT_2α (FR727107), and Dm5-HT_2α (CAA57429). The divergent D. melanogaster ninaE-encoded rhodopsin 1 (DmninaE, NM_079683) and D. melanogaster FMRFamide receptor (DmFR, AAF47700) were used as out-groups. The numbers at the nodes of the branches represent the percentage bootstrap support (2,000 replications) for each branch.