Table 2. Effects of FA on LPS-Induced IUGR.
| Control | FA | LPS | LPS+FA (0.6 mg/kg ) | LPS+FA (3 mg/kg) | LPS+FA (15 mg/kg) | |
|---|---|---|---|---|---|---|
| Number of pregnant mice (n) | 11 | 11 | 11 | 11 | 11 | 11 |
| Litters of preterm delivery (n) | 0 | 0 | 1 | 1 | 0 | 0 |
| Litters of term delivery (n) | 11 | 11 | 10 | 10 | 11 | 11 |
| Dead fetuses per litter (n) a | 0.18±0.12 | 0.09±0.09 | 4.10±1.22** | 3.10±1.18 | 1.18±0.42‡ | 0.91±0.31‡ |
| Live fetuses per litter (n) a | 13.09±0.71 | 13.73±0.43 | 10.56±1.27 | 11.67±0.58 | 11.82±0.67 | 12.09±0.68 |
| Fetal weight (g) | 1.39±0.02 | 1.39±0.01 | 1.16±0.02** | 1.26±0.03‡‡ | 1.24±0.02‡‡ | 1.30±0.02‡‡ |
| Crown-rump length (cm) | 2.45±0.01 | 2.47±0.01 | 2.34±0.03** | 2.38±0.02 | 2.38±0.01 | 2.41±0.02‡ |
| Average placental weight (g) | 1.101±0.002 | 1.102±0.002 | 0.088±0.003** | 0.091±0.003 | 0.090±0.003 | 0.094±0.004 |
Note. In the LPS group, the pregnant mice received an i.p. injection of LPS (75 μg/kg/d) on GD15-GD17.
In LPS+FA groups, the pregnant mice were orally administered with different doses of FA (0.6, 3 or 15 mg/kg/d) 1 h before LPS injection.
All quantitative data were presented as means ± SEM.
a The number of dead or live fetuses per litter in dams that completed the pregnancy.
* P < 0.05, ** P < 0.01 VS the control; ‡ P < 0.05, ‡‡ P < 0.01 VS LPS group.