Table 3.

Inhibition of DHODs

Compound	TgDHOD		PfDHOD		HsDHOD
	IC50 μM	Ki μM	IC50 μM	$K_i^{\mathit{app}}\mu M$	IC50 μM	$K_i^{\mathit{app}}\mu M$
A77-1726	91 ± 2	45	190 ± 10 [14]	22 [17]	1.08 ± 0.1 [34] 0.26 ± 0.10 [13]	0.032 [17]
MD209	60 ± 8	18	8.6 [17]	1.0 [17]	0.20 [17]	0.025 [17]
MD249	96 ± 18	16	9.9 [17]	1.2 [17]	0.33 [17]	0.040 [17]
DSM190	>100	–	0.19 [16]	–	>30 [16]	–

⁽¹³⁾ Baldwin et al., 2005; ⁽¹⁴⁾ Heikkila et al., 2007; ⁽¹⁶⁾ Gujjar et al., 2011; ⁽¹⁷⁾ Davies et al., 2009; ⁽³⁴⁾ Knecht et al., 1998. IC₅₀ values for TgDHOD are followed by standard deviations.