. Author manuscript; available in PMC: 2013 Dec 7.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2012 Jan 19;83(1):10.1016/j.ijrobp.2011.06.1990. doi: 10.1016/j.ijrobp.2011.06.1990

Table 3.

Biologically equivalent doses of conventional and hypofractionated radiotherapy regimens, with and without the addition of chemotherapy

Disease	RT Schedule [reference]	RT: Mean EQD2 (95% CI)	RT+Chemo: Mean EQD2 (95% CI)	Mean EQD2 increase	p
GBM	2.0 Gy x 30 fx = 60 Gy(8)	60.0 Gy (NA)	121.3 Gy (97.9 to 144.7 Gy)	102%	0.002
GBM	6.0 Gy x 5 fx = 30 Gy(51)	51.6 Gy (40.6 to 62.6 Gy)	77.8 Gy (72.3 to 83.3 Gy)	39%	0.015
HNC	2.0 Gy x 35 fx = 70 Gy(52)	70.0 Gy (NA)	105.2 Gy (81.3 to 129.1 Gy)	50%	0.034
HNC	5.0 Gy x 6 fx = 30 Gy(53, 54)	38.4 Gy (32.3 to 44.6 Gy)	49.7 Gy (39.5 to 59.9 Gy)	28%	0.045
NSCLC	2.0 Gy x 30 fx = 60 Gy(10)	60.0 Gy (NA)	161.6 Gy (74.1 to 249.2 Gy)	169%	0.063
NSCLC	10.0 Gy x 5 fx = 50 Gy(55, 56)	111.5 Gy (99.4 to 123.5 Gy)	159.3 Gy (139.9 to 178.6 Gy)	42%	0.001
Pancreas	1.8 Gy x 28 fx = 50.4 Gy(57)	46.8 Gy (46.2 to 47.4 Gy)	62.4 Gy (42.8 Gy to 82.1 Gy)	34%	0.175
Pancreas	10.0 Gy x 3 fx = 30 Gy(58)	75.2 Gy (64.6 to 85.7 Gy)	133.8 Gy (97.1 to 170.5 Gy)	82%	0.007

Modeled radiotherapy (RT) fractionation schedules. (fx = fraction, EQD2 = biologically equivalent dose of RT given in 2 Gy fractions, NA = not applicable)