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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: Mol Cell. 2013 May 23;50(4):10.1016/j.molcel.2013.04.032. doi: 10.1016/j.molcel.2013.04.032

Figure 6. Model for RPA-mediated coordination of DNA end processing.

Figure 6

Mre11 and Sae2 initiate resection to form short 3’ tails. In the absence of RPA Dna2 is not recruited to the break site, extensive resection is eliminated, and the 3’ overhangs tend to form secondary structures by annealing between short repeats. Following annealing between inverted repeats, the 3’ unpaired flap is trimmed and after DNA synthesis is ligated to the 5’ end to form a hairpin. The 3’ strand loss could occur by Mre11-dependent degradation of 3’ ends or by hairpin cleavage before (shown) or after DNA synthesis and ligation.