Table 2.

Associations of BMP4 SNPs with type 2 diabetes.

SNP	Chr. position (Build 37.3)	Major/minor allele	Risk allele	Cases (n = 3410)		Controls (n = 3412)		OR for risk allele (95% CI)	P value for risk allele	OR for genotype (95% CI)	P value for genotype (empirical P value)
				Risk allele frequencies	Genotype count 11/12/22#	Risk allele frequencies	Genotype count 11/12/22#
rs1951867	54407192	G/C	G	0.903	2748/586/35	0.896	2673/617/36	1.073 (0.959, 1.201)	0.220	1.071 (0.957, 1.198)	0.233
rs7146040	54407920	A/G	G	0.097	2755/586/36	0.096	2768/572/38	1.017 (0.908, 1.140)	0.767	0.983 (0.878, 1.101)	0.769
rs4444235	54410919	T/C	C	0.459	996/167/717	0.452	1034/1593/716	1.026 (0.959, 1.098)	0.461	0.975 (0.912, 1.043)	0.465
rs17563	54417522	T/C	T	0.720	1800/1319/273	0.717	1733/1375/269	1.042 (0.967, 1.124)	0.280	1.042 (0.967, 1.123)	0.283
rs2071047	54418411	C/T	T	0.368	1380/1522/485	0.355	1428/1527/444	1.056 (0.985, 1.133)	0.126	0.948 (0.885, 1.016)	0.131
rs2761887	54425052	C/A	A	0.519	793/1675/920	0.511	795/1674/866	1.033 (0.965, 1.105)	0.348	0.968 (0.905, 1.036)	0.348
rs8014071	54431500	A/G	G	0.350	1426/1572/404	0.341	1462/1539/386	1.039 (0.968, 1.115)	0.290	0.962 (0.896, 1.033)	0.287
rs8014363	54431575	T/C	T	0.884	2617/690/45	0.873	2574/774/45	1.108 (0.999, 1.229)	0.051	1.110 (1.000, 1.231)	0.050 (0.3689)
rs7141785	54433114	C/T	C	0.904	2740/572/36	0.902	2727/594/32	1.028 (0.916, 1.154)	0.639	1.022 (0.912, 1.146)	0.705
rs6572927	54433390	T/A	T	0.633	1345/1534/456	0.632	1327/1533/455	1.008 (0.940, 1.082)	0.816	1.008 (0.939, 1.081)	0.834

P values <0.1 were shown in bold.

The additive model was used in the association analyses between genotype and type 2 diabetes.

^#11: major allele homozygotes; 12: heterozygotes; 22: minor allele homozygotes. Empirical P values are for the alleles based on 10,000 permutations.