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. 2013 Oct 28;14(11):21378–21393. doi: 10.3390/ijms141121378

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

AKIP1 activates the Akt pathway and downstream proteins controlling protein synthesis. Western blot analysis of samples from AdControl and AdAKIP1 infected NRVCs after 48 h expression. The indicated proteins were detected and the prefix p- indicates the phosphorylated protein and the prefix t- indicates the total protein. GAPDH was used as a loading control. (A) AKIP1 overexpressing NRVCs did not induce ERK phosphorylation (n = 4); (B) Akt phosphorylation was significantly up-regulated in AKIP1 overexpressing cells (*p < 0.05, n = 4); (C) Phosphorylation of rpS6 was significantly induced in AKIP1 overexpressing cells (*p < 0.05, n = 4); (D) Less eEF2 phosphorylation was observed in AKIP1 infected cardiomyocytes (*p < 0.05, n = 4).