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. 2013 Nov 11;14(11):22221–22232. doi: 10.3390/ijms141122221

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Treatment of stroke with BMSCs, Niaspan and combination BMSCs+Niaspan all significantly increased SMI-31 (A, p < 0.05) expression compared to T1DM-MCAo control. Niaspan and combination BMSCs+Niaspan treatment both increased Synaptophysin (B, p < 0.05) expression in the ischemic brain compared to T1DM-MCAo control. Combination treatment additively increases Synaptophysin expression compared to BMSCs monotherapy rats (p < 0.05). Group number in T1DM-MCAo: n = 8; Niaspan-alone: n = 10; BMSCs-alone: n = 8; BMSCs + Niaspan: n = 7. * p < 0.05 vs. T1DM-MCAo control.