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Anxiolytic and hypnotic neuroprotective effects in Huntington’s disease models.
| Neuroprotective action | Cyproheptadine | Melatonin |
|---|---|---|
| Huntingtin clearance | ||
| AP-1 DNA binding | ||
| Histone acetylation | ||
| p53 | ||
| MiR-222 | ||
| Mitochondria | + | |
| Apoptosis | + | + |
| Neurogenesis | ||
| BDNF | ||
| Striatal preservation | ||
| Cognitive integrity | ||
| Motor integrity | ||
| Delay of disease onset | + | |
| Enhanced survival | + |
