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. 2013 Nov 18;14(11):22697–22707. doi: 10.3390/ijms141122697

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Knockdown of the receptor for AGE (RAGE) inhibits AGE-induced activation of JNK in ECV304 cells. (A) Western blotting shows the effect of siRNA-RAGE on expression of RAGE; (C) Western blotting shows that knockdown of RAGE via siRNA-RAGE results in significant inhibition of JNK activation induced by AGEs; (B,D) The statistical results of (A) and (C) show (*) siRNA-RAGE (SIR-Rage) vs. siRNA control (Sir-Ctrl); AGEs vs. (a) Lipofectamine 2000 control (Lipo); (b) Non-targeting siRNA control (Sir-Ctrl); and (c,d) siRNA-RAGE (SIR-Rage) or Sir-Ctrl. All results gave p < 0.05. Results are from three independent experiments; β-actin was used as an internal control.