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Models of RNA-PTB interaction in exon splicing repression. (A) Repression by PTB looping out a branch-point adenosine; (B) PTB monomer looping-out an exon; (C) Multiple PTB molecules binding cooperatively around an alternative exon; (D) PTB cooperates with the co-factor Raver1 to loop out an alternative exon by binding to distant intronic pyrimidine tracts.
