Table 2.
Distribution of CD14 polymorphism and haplotypes by asthma, atopy, and croup.
| Asthma (n = 533) | Atopy (n = 499) | Croup (n = 533) | ||||
|---|---|---|---|---|---|---|
| Yes n (%) |
No n (%) |
Yes n (%) |
No n (%) |
Yes n (%) |
No n (%) |
|
| Genotypes | ||||||
| CD14 C-159T | ||||||
| C/C | 30 (19.2) | 126 (80.8) | 31 (21.8) | 111 (78.2) | 4 (2.6)1 | 152 (97.4) |
| C/T | 53 (18.8) | 229 (81.2) | 55 (20.5) | 213 (79.5) | 23 (8.2) | 259 (91.8) |
| T/T | 16 (16.8) | 79 (83.2) | 26 (29.2) | 63 (70.8) | 8 (8.4) | 87 (91.6) |
| CD14 G-1359T | ||||||
| G/G | 47 (15.6)2 | 254 (84.4) | 68 (23.6) | 220 (76.4) | 22 (7.3) | 279 (92.7) |
| G/T | 41 (21.5) | 150 (78.5) | 33 (18.9) | 142 (81.1) | 11 (5.8) | 180 (94.2) |
| T/T | 11 (26.8) | 30 (73.2) | 11 (30.6) | 25 (69.4) | 2 (4.9) | 39 (95.1) |
| Haplotypes | ||||||
| C|G | 28 (16.9)3 | 138 (83.1) | 31 (19.9) | 125 (80.1) | 8 (4.8) | 158 (95.2) |
| C|T | 29 (22.0) | 103 (78.0) | 27 (22.7) | 92 (77.3) | 8 (6.1) | 124 (93.9) |
| T|G | 39 (17.0) | 191 (83.0) | 53 (24.2) | 166 (75.8) | 19 (8.3) | 211 (91.7) |
| T|T | 3 (60.0) | 2 (40.0) | 1 (20.0) | 4 (80.0) | 0 (0.0) | 5 (100.0) |
n number and the numbers in parenthesis are the percentages. For genotype and haplotype analysis, significance difference of yes/no groups was performed using Fisher's exact test.
1 P = 0.05, 2P = 0.10, 3P = 0.06.