TABLE 2.

Univariate and Multivariate Analysis of Clinicopathologic Variables Associated With DFS in 341 Patients Who Underwent Hepatectomy for Metachronous CLM

Variable		Univariate Analysis			Multivariate Analysis*
		N = 341 (%)	Median DFS, mo	P	HR	95% CI	P
Sex	Male	60	19	0.340
	Female	40	20
Age, y	>65	35	19	0.268
	≤65	65	20
Primary tumor	Rectal	29	20	0.820
	Colon	71	18
Lymph nodes for primary	Positive	54	16	0.023			NS
	Negative	46	25
Number CLM	Multiple	61	15	0.065
	Solitary	39	22
Adjuvant therapy for CRC	None	28	29	< 0.0001	1.52	1.23–1.89	< 0.0001
	5-FU	49	20
	FOLFOX	23	12
Size, cm	> 3	47	20	0.434
	≤3	53	18
CEA, ng/mL	> 5	51	17	0.924
	≤5	49	16
Preoperative chemotherapy for CLM	Yes	55	15	0.028			NS
	No	44	25
Portal vein embolization	Yes	7	11	0.174
	No	93	20
Transfusions	Yes	10	16	0.602
	No	90	20
Positive surgical margins at CLM resection	Yes	12	13	0.012			NS
	No	88	20
Pathologic response to preoperative chemotherapy for CLM (n = 189)	Major	48	16	0.089
	Minor	52	12
Postoperative chemotherapy for CLM	Yes	64	18	0.113
	No	36	23
Complications	Yes	27	19	0.687
	No	73	20

^*Cox regression multivariate analysis included all variables with P < 0.05 in univariate analysis.

NS indicates not significant.