TABLE 3.

Univariate and Multivariate Analysis of Clinicopathologic Variables Associated With OS in 341 Patients Who Underwent Hepatectomy for Metachronous CLM

Variable		Univariate Analysis			Multivariate Analysis*
		N = 341 (%)	Median OS, mo	P	HR	95% CI	P
Sex	Male	60	61	0.087
	Female	40	94
Age, y	> 65	35	59	0.103
	≤65	65	94
Primary	Rectal	29	94	0.265
	Colon	71	65
Lymph nodes for primary	Positive	54	59	0.022			NS
	Negative	46	94
Number CLM	Multiple	61	53	0.009	1.52	1.07–2.17	0.021
	Solitary	39	108
Adjuvant therapy for CRC	None	28	NR	0.002	1.86	1.36–2.53	< 0.0001
	5-FU	49	70
	FOLFOX	23	40
Size, cm	>3	47	50	0.002	1.89	1.31–2.73	0.001
	≤3	53	NR
CEA, ng/mL	>5	51	57	0.209
	≤5	49	71
Preoperative chemotherapy for CLM	Yes	55	76	0.978
	No	44	72
Portal vein embolization	Yes	7	45	0.534
	No	93	71
Transfusions	Yes	10	41	0.227
	No	90	71
Positive surgical margins at CLM resection	Yes	12	40	0.003	1.82	1.13–2.93	0.014
	No	88	77
Pathologic response to preoperative chemotherapy for CLM (n = 189)	Major	48	NR	0.264
	Minor	52	114
Postoperative chemotherapy for CLM	Yes	64	67	0.417
	No	36	82
Complications	Yes	27	57	0.129
	No	43	75

^*Cox regression multivariate analysis included all variables with P < 0.05 in univariate analysis.

NR indicates not reached; NS, not significant.