Table 3.
Univariate and Multivariate Analysis of Factors Associated with Overall Survival (OS) in 193 Patients Who Underwent Somatic Gene Mutation Analysis
| Factor | 3-year OS (%) |
5-year OS (%) |
Univariate Analysis P Value |
Multivariate Analysis | |
|---|---|---|---|---|---|
| P Value | Hazard Ratio (95% CI) | ||||
| Disease-free intervala | |||||
| <12 months (n=130) | 72.7 | 58.3 | 0.197 | ||
| ≥12 months (n=63) | 84 | 69 | |||
| Primary tumor location | |||||
| Rectum (n=39) | 71.8 | 54.2 | 0.611 | ||
| Colon (n=154) | 77.2 | 63.4 | |||
| Primary tumor nodal status | |||||
| Positive (n=133) | 72.5 | 53 | 0.004 | NS | |
| Negative (n=60) | 85 | 81.3 | |||
| RAS mutation status | |||||
| Mutant (n=34) | 52.2 | 44.7 | 0.002 | 0.002 | 2.26 (1.13 – 4.51) |
| Wild-type (n=159) | 81 | 65.4 | |||
| No. of cycles of preoperative chemotherapy | |||||
| >6 (n=65) | 65.5 | 51.2 | 0.017 | NS | |
| ≤6 (n=128) | 83.2 | 69 | |||
| Pathologic response | |||||
| %VTC ≥50% (n=87) | 65.2 | 45.2 | <0.001 | 0.022 | 2.10 (1.11 – 3.97) |
| %VTC <50% (n=106) | 86.1 | 64.5 | |||
| No. of CLM | |||||
| Multiple (n=125) | 73 | 58.4 | 0.160 | ||
| Single (n=68) | 82.8 | 67.8 | |||
| Diameter of largest of CLM | |||||
| >5 cm (n=24) | 58.9 | 46.4 | 0.030 | NS | |
| ≤5 cm (n=169) | 79.1 | 64.3 | |||
| Major complication | |||||
| Yes (n=32) | 64.1 | 53 | 0.108 | ||
| No (n=161) | 77.6 | 62 | |||
| Surgical margin | |||||
| Negative (n=174) | 75.1 | 59.1 | 0.312 | ||
| Positive (n=19) | 86.5 | 86.5 | |||
CLM indicates colorectal liver metastases; NS, not significant; %VTC, percentage viable tumor cells.
a
From diagnosis of primary tumor to diagnosis of CLM.