Table 4.
Univariate and Multivariate Analysis of Factors Associated with Lung Recurrence after Resection of CLM
| Factor | 3-year Lung RFS (%) |
Univariate Analysis P Value |
Multivariate Analysis | |
|---|---|---|---|---|
|
P Value |
Hazard Ratio (95% CI) | |||
| Disease-free intervala | ||||
| <12 months (n=130) | 52.7 | 0.680 | ||
| ≥12 months (n=63) | 59.7 | |||
| Primary tumor location | ||||
| Rectum (n=39) | 34.3 | 0.016 | 0.069 | |
| Colon (n=154) | 59.4 | |||
| Primary tumor nodal status | ||||
| Positive (n=133) | 52.8 | 0.511 | ||
| Negative (n=60) | 59.7 | |||
| RAS mutation status | ||||
| Mutant (n=34) | 34.6 | <0.001 | 0.01 | 2.01 (1.20 – 3.41) |
| Wild-type (n=159) | 59.3 | |||
| No. of cycles of preoperative chemotherapy | ||||
| >6 (n=65) | 54.6 | 0.976 | ||
| ≤6 (n=128) | 55.9 | |||
| Pathologic response | ||||
| %VTC ≥50% (n=87) | 39.7 | 0.001 | 0.009 | 1.91 (1.17 – 3.10) |
| %VTC <50% (n=106) | 64.5 | |||
| No. of CLM | ||||
| Multiple (n=125) | 50.3 | 0.062 | NS | |
| Single (n=68) | 66 | |||
| Diameter of largest of CLM | ||||
| >5 cm (n=24) | 45.5 | 0.04 | NS | |
| ≥5 cm (n=169) | 56.4 | |||
| Major complication | ||||
| Yes (n=32) | 34.2 | 0.164 | ||
| No (n=161) | 57.7 | |||
| Surgical margin | ||||
| Positive (n=19) | 81.3 | 0.295 | ||
| Negative (n=174) | 73.1 | |||
CLM indicates colorectal liver metastases; NS, not significant; RFS, recurrence-free survival; %VTC, percentage viable tumor cells.
a
From diagnosis of primary tumor to diagnosis of CLM.