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Average dopamine and serotonin transporter occupancy vs. oral dose of SEP-225289. Dopamine transporter occupancy was measured in dorsal caudate and dorsal putamen using PET with 11C-PE2I. Serotonin transporter occupancy was measured in dorsal caudate, dorsal putamen, and midbrain using PET with 11C-DASB. Each symbol represents mean value across all subjects in single cohort. Error bars indicate SD across cohort subjects. DAT = dopamine transporter; SERT = serotonin transporter.
