Table 2.
Select performance parameters of some commercially available mass spectrometers
| Parameter | TSQ quantum access max | TSQ quantiva | LTQ-orbitrap velos | Qq-ToF | Synapt G2-S HDMS | Q-exactive | Agilent 6540 | Orbitrap fusion tribrid |
| Acquisition rate | 5000 amu/s | 15000 amu/s | 1/s@60000 RP | 3/s@30000 RP | 30/s MS or MSe mode | 13/s@17500 | 20 MS/s | 15/sec@15000 |
| 3/s@15000 RP | 2000/s IMS mode | 1.5/s@140000 | 10 MS2/s | |||||
| Linear dynamic range | 5 orders | 6 orders | 5-6 orders | 2-3 orders | > 5 orders In-spectrum1 | > 5 orders | 5 orders | > 5 orders |
| Mass accuracy | 0.1 Da | 0.1 Da | < 3 ppm MS | < 5 ppm Full scan w/Lock Mass | < 1 ppm MS MSe or MS/MS | < 1 ppm | < 1 ppm MS | < 1 ppm |
| < 3 ppm MSn | > 100 ppm MS/MS | < 2 ppm MS2 | < 1 ppm MSn | |||||
| (no lock mass) | ||||||||
| Resolution | 0.4 Da FWHM | 0.2 Da FWHM | > 100000 RP | Up to 30000 RP | Up to 40000RP | 140000 | > 15000 RP@ 1522 | 450000 |
| Sensitivity | Sub-femto-mol | Atto-mol | Sub atto-mol | Sub femto-mol | Approximately 10 charges at the detector | Atto-mol | Femto-mol | Sub atto-mol |
1
At full resolution and maximum acquisition rate. ToF: Time of flight; LTQ: Linear trap quadropole; TSQ: Triple stage quadrupole; HDMS: High definition mass spectrometry; MS: Mass spectrometry; IMS: Ion mobility spectometry.