Table D.

6 among 37 pathways are significant with either WKS-Variant or Direct-SKAT pathway level analysis (significance level = 0.05). These 6 pathways each includes at least one of 4 genes in Table C. Pathways are accompanied with their p-values with WKS-Variant and Direct-SKAT methods. At last line of table, we combine all 4 genes in one gene-set.

Pathway	Source	Description	Gene Number Within	Gene Number in Table C	p-value (WKS-Va riant)	p-value (Direct-S KAT)
erythPathway	BIOCARTA	Erythrocyte Differentiation Pathway	12	2	0.0476	0.3301
hsa04620	KEGG	Toll-like receptor signaling pathway	58	1	0.4419	0.0278
hsa04630	KEGG	Jak-STAT signaling pathway	99	2	0.4923	0.0064
hsa05210	KEGG	Colorectal cancer	53	1	0.3863	0.0078
hsa05211	KEGG	Renal cell carcinoma	35	1	0.2622	0.0276
hsa05220	KEGG	Chronic myeloid leukemia	44	1	0.2032	0.0062
---	Table C	Combine all 4 genes in Table C	4	4	0.0010	0.2932