FIGURE 2.

Metabolic models consist in an ensemble of metabolic pools, connected by metabolic fluxes respecting the steady-state condition for metabolic pools.(A) Example of a simple metabolic model used to illustrate how to write ¹³C-labeling equations; metabolic pools A and B yield C at rates V₁ and V₂, respectively; (B) a “classical” two-compartment metabolic model (see main text for model’s description). αKG, α-ketoglutarate; Asp, aspartate; Glc, glucose; Gln, glutamine; Glu, glutamate; Lac, lactate; OAA, oxaloacetate; Pyr, pyruvate; Suc, succinate.