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. 2013 Sep 27;11:237. doi: 10.1186/1479-5876-11-237

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Copyright © 2013 Castelli et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Macrophages are key components of the inflammatory microenvironment in metastatic alveolar soft part sarcoma. Immunohistochemical analysis of CD163+ cells infiltrating an untreated ASPS lesion (A-B). As evidenced by the higher magnification image these cells are found in two distinct localizations: they are interspersed within nest tumor cells (circle) and they are also detectable in the perivascular region (arrows). (B) Confocal microscopy imaging of CD163+ cells (green) shows that they are aligned to endothelial VEGFR2+ cells (red) (C). CD14 staining closely resembles that of CD163 (D) and double staining confirms that CD31+ endothelial cells (green) are lined by CD14+ macrophages (red). (E) A similar distribution of immunoreactivity is observed for CSFR-1 (F).