Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Oct 8;13:463. doi: 10.1186/1471-2407-13-463

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2013 Cross-Knorr et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Oxaliplatin (OXP) reduces the phosphorylation of STAT3 and RKIP that is induced by interleukin-6 (IL-6). Western blot analysis of: (A) the indicated proteins in HCT116 cells treated with IL-6 (40 ng/ml) for 1–6 h. (B) HCT116 cells treated with 300 μM OXP, IL-6 (40 ng/ml) in serum free medium or the combination for 16 h and analyzed for the indicated proteins via Western blot analysis. (C) Cell extracts were prepared after 18 h following treatment with OXP, IL-6 or the combination for flow cytometric analysis to examine binding to 7-AAD and annexin-V (% Apoptosis). The % Apoptosis of each sample is indicated in the top right corner of every panel: a) untreated control cells (0.20%); b) 5 μM STS (70.94%); 300 μM OXP (31.04%); d) IL-6 (4.01%); e) OXP + IL-6 (19.56%). STS is the positive control. The figure is representative of part of 1 experiment performed in duplicate. The experiment was repeated twice.