Table 1.
Model parameters values and references: base case and sensitivity analysis
| Base case | Sensitivity analysis | References | ||
|---|---|---|---|---|
|
Parameter |
|
Lower limit |
Upper limit |
|
| Kidney cancer incidence 40+ (per 100,000) |
19.8 |
17.82 |
21.78 |
[22] |
| RCC incidence (over kidney cancer incidence) |
90% |
85% |
95% |
[24,25] |
| RCC incidence at diagnosis (over RCC incidence) |
20% |
15% |
25% |
[24,25] |
| RCC mortality (localized disease) |
1.66% |
1.49% |
1.83% |
[23] |
| Transition to advanced RCC (year 1) |
13.18% |
11.86% |
14.49% |
[20] |
| Transition to advanced RCC (years 2 and 3) |
4.57% |
4.11% |
5.02% |
[20] |
| Transition to advanced RCC (years 4 and 5) |
1.92% |
1.73% |
2.11% |
[20] |
| Transition to advanced RCC (year 6 and 7) |
1.64% |
1.48% |
1.81% |
[20] |
| Transition to advanced RCC (year 8 to 10) |
1.26% |
1.13% |
1.38% |
[20] |
| Advanced RCC of favorable or intermediate risk |
89% |
80.1% |
97.9% |
[26] |
| Transition to post-advanced RCC | 100% | [7,13] | ||