Table 2.
Ten most frequent influenza A HA discontinuous peptides on neutralizing epitope region recognized by neutralizing antibody F10 in FluKB (29,113 complete HA protein sequences). The table shows the amino acids of the epitope, HA subtype, frequency within the data set, and validation status - escape variants are those strains not neutralized by the F10.
| # | Discontinuous peptide | Subtype | Frequency (%) | Accumulated frequency (%) |
Validation |
|---|---|---|---|---|---|
| 1 | HHVLSLPTVDGWLTQITVNI | H1 | 24.61 | 24.61 | N/A |
| 2 | HNTLDKPTVDGWLTQINLNI | H3 | 15.64 | 40.25 | Escape |
| 3 | HHQISMPTVDGWKTQITVNI | H5 | 13.49 | 53.74 | Neutralized |
| 4 | HHVLSLPTVDGWQTQITVNI | H1 | 7.61 | 61.35 | N/A |
| 5 | QHKLTLPVVAGWRTQITVNV | H9 | 3.93 | 65.28 | Neutralized |
| 6 | HNTLDKPTIDGWLTQINLNI | H3 | 3.51 | 68.79 | N/A |
| 7 | THALSKPNIAGWLTQITLNS | B | 2.95 | 71.74 | N/A |
| 8 | HHVLSLPTIDGWQTQITVNI | H1 | 2.61 | 74.35 | Neutralized |
| 9 | HHVLNKTTIDGWRTQITVNI | H6 | 1.99 | 76.34 | N/A |
| 10 | HTQLTKPTIDGWLTQINLNI | H4 | 1.59 | 77.93 | N/A |