Table 3.
Frequency and allele distribution of discontinuous motifs in binding pocket 1 β chain of the DRB1 protein from the MSA of 947 DRB1 sequences. The “NA” stands for rare alleles where major and minor serogroups could not be defined, with their observed serotypes given in the brackets. These rare alleles represent 2.85% of all HLA-DRB1 sequences that are likely to have different binding specificities of peptide repertoires than those that belong to the major serogroups.
| # | Discontinuous peptide |
Frequency (%) | Accumulated frequency (%) |
Number of sequences |
DRB1 serogroup signatures |
|---|---|---|---|---|---|
| 1 | HNVVFT | 45.62 | 45.62 | 432 | 03, 13, 14, 15 (major) 04, 11 (minor) |
| 2 | HNVGFT | 45.51 | 91.13 | 431 | 01, 04, 07, 08, 09, 10, 11, 16 (major) 03, 14, 15 (minor) |
| 3 | HNAVFT | 6.02 | 97.15 | 57 | 12 (major) 01 (minor) |
| 4 | YNVVFT | 0.53 | 97.68 | 5 | NA (04, 14, 15) |
| 5 | YNVGFT | 0.42 | 98.10 | 4 | NA (04, 11, 15) |
| 6 | HNVDFT | 0.32 | 98.42 | 3 | NA (07, 11, 13) |
| 7 | HSVVFT | 0.21 | 98.63 | 2 | NA (03, 13) |
| 8 | HNVSFT | 0.21 | 98.84 | 2 | NA (08, 13) |
| 9 | HNVAFT | 0.21 | 99.05 | 2 | NA (03) |
| 10 | HNVMFT | 0.21 | 99.26 | 2 | NA (13, 14) |
| 11 | RNVVFT | 0.11 | 99.37 | 1 | NA (15) |
| 12 | HNFGFT | 0.11 | 99.47 | 1 | NA (13) |
| 13 | HNLGFT | 0.11 | 99.58 | 1 | NA (11) |
| 14 | QNVGFT | 0.11 | 99.68 | 1 | NA (11) |
| 15 | HNIGFT | 0.11 | 99.79 | 1 | NA (11) |
| 16 | HNIVFT | 0.11 | 99.89 | 1 | NA (03) |
| 17 | DNVGFT | 0.11 | 100.00 | 1 | NA (01) |