Table 2.
Top ranked SNPs associated with breast cancer risk in African American and European American women
| Gene/miRNA | SNP | Genotype | AA | EA | P for interaction with race |
||||
|---|---|---|---|---|---|---|---|---|---|
| # Case/Control |
OR (95% CI) | P | # Case/Control | OR (95% CI) | P | ||||
| AGO4 | rs7354931 | CC | 429/356 | 1.00 | 0.03 | 326/306 | 1.00 | 0.99 | 0.47 |
| CA/AA | 42/55 | 0.63 (0.41–0.96) | |||||||
| PACT | rs2059691 | GG/GA | 445/389 | 1.00 | 0.92 | 283/283 | 1.00 | 0.04 | 0.22 |
| AA | 24/21 | 1.03 (0.56–1.89) | 46/27 | 1.72 (1.03–2.87) | |||||
| hsa-miR-106b | rs1527423 | AA | 37/37 | 1.00 | 0.64 | 90/110 | 1.00 | 0.02 | 0.37 |
| AG/GG | 436/375 | 1.12 (0.69–1.82) | 238/200 | 1.50 (1.07–2.11) | |||||
| hsa-miR-100 | rs1834306 | GG/GA | 248/221 | 1.00 | 0.77 | 267/230 | 1.00 | 0.03 | 0.05 |
| AA | 225/191 | 1.04 (0.8–1.36) | 62/79 | 0.64 (0.44–0.95) | |||||
| hsa-miR-331 | rs11107973 | AA/AG | 305/285 | 1.00 | 0.18 | 256/267 | 1.00 | 0.02 | 0.18 |
| GG | 169/127 | 1.22 (0.92–1.62) | 72/42 | 1.65 (1.08–2.52) | |||||
| hsa-miR-758 | rs12586258 | GG | 417/336 | 1.00 | 0.01 | 169/170 | 1.00 | 0.33 | 0.01 |
| GA/AA | 56/76 | 0.61 (0.42–0.89) | 159/140 | 1.17 (0.85–1.6) | |||||
| hsa-miR-544 | rs10144193 | AA | 187/167 | 1.00 | 0.81 | 198/219 | 1.00 | 0.004 | 0.03 |
| AT/TT | 287/244 | 1.03 (0.79–1.36) | 130/91 | 1.65 (1.18–2.31) | |||||
| has-mir-487 | rs1951032 | GG | 430/364 | 1.00 | 0.23 | 176/198 | 1.00 | 0.001 | 0.005 |
| GA/AA | 38/44 | 0.75 (0.47–1.19) | 110/73 | 1.81 (1.26–2.61) | |||||
| hsa-miR-659 | rs5750504 | TT | 145/110 | 1.00 | 0.19 | 98/118 | 1.00 | 0.03 | 0.01 |
| TA/AA | 328/302 | 0.82 (0.61–1.10) | 231/192 | 1.45 (1.04–2.03) | |||||
| hsa-miR-513a-2 | rs2018562 | AA | 133/143 | 1.00 | 0.04 | 190/178 | 1.00 | 0.97 | 0.36 |
| AG | 225/193 | 1.25 (0.92–1.70) | 117/113 | 0.97 (0.70–1.36) | |||||
| GG | 115/75 | 1.64 (1.13–2.39) | 22/19 | 1.04 (0.54–2.01) | |||||
| Per copy G allele | 1.28 (1.06–1.54) | 0.01 | 1.00 (0.77–1.29) | 0.98 | 0.12 | ||||
*
Footnote: Odds ratios and p-values adjusted for age, body mass index (BMI), proportion of European ancestry, family history of breast cancer, and education.
Abbreviations: OR: odds ratio; CI: confidence interval.