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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Breast Cancer Res Treat. 2013 Sep 24;141(3):447–459. doi: 10.1007/s10549-013-2698-4

Table 4.

Top ranked SNPs associated with estrogen receptor (ER) negative breast cancer risk in African American and European American women

Gene SNP Genotype AA EA P for
interaction
with race


# Case/Control OR (95% CI) P # Case/Control OR (95% CI) P
hsa-miR-219 rs107822 GG 29/174 1.00 0.004 24/180 1.00 0.17 0.5
GA/AA 78/235 1.99 (1.24–3.19) 27/130 1.52 (0.84–2.77)
hsa-mir-595 rs4909238 AA/AG 77/338 1.00 0.03 37/248 1.00 0.16 0.81
GG 27/70 1.76 (1.05–2.95) 14/61 1.64 (0.82–3.26)
hsa-miR-204 rs7861254 GG 37/106 1.00 0.04 28/166 1.00 0.77 0.3
vs. GG 70/306 0.62 (0.39–0.99) 23/144 0.91 (0.5–1.67)
hsa-miR-608 rs4919510 CC 43/153 1.00 0.42 41/204 1.00 0.03 0.18
CG/GG 64/259 0.83 (0.54–1.29) 10/106 0.45 (0.21–0.94)
hsa-miR-758 rs7141987 AA 2/19 1.00 0.36 8/94 1.00 0.03 0.83
AG/GG 104/392 2.01 (0.45–8.93) 43/210 2.41 (1.08–5.37)
hsa-miR-495 rs2281611 CC 62/233 1.00 0.92 15/151 1.00 0.01 0.03
CA/AA 45/179 0.98 (0.63–1.51) 36/159 2.29 (1.19–4.39)
hsa-miR-513a-2 rs2018562 AA 25/143 1.00 0.03 26/178 1.00 0.33 0.46
AG/GG 82/268 1.74 (1.06–2.86) 25/132 1.35 (0.74–2.47)
*

Footnote: Odds ratios and p-valuesadjusted for age, body mass index (BMI), proportion of European ancestry, family history of breast cancer, and education.

Abbreviations: OR: odds ratio; CI: confidence interval; ER: estrogen receptor