Table 4.
Top ranked SNPs associated with estrogen receptor (ER) negative breast cancer risk in African American and European American women
| Gene | SNP | Genotype | AA | EA | P for interaction with race |
||||
|---|---|---|---|---|---|---|---|---|---|
| # Case/Control | OR (95% CI) | P | # Case/Control | OR (95% CI) | P | ||||
| hsa-miR-219 | rs107822 | GG | 29/174 | 1.00 | 0.004 | 24/180 | 1.00 | 0.17 | 0.5 |
| GA/AA | 78/235 | 1.99 (1.24–3.19) | 27/130 | 1.52 (0.84–2.77) | |||||
| hsa-mir-595 | rs4909238 | AA/AG | 77/338 | 1.00 | 0.03 | 37/248 | 1.00 | 0.16 | 0.81 |
| GG | 27/70 | 1.76 (1.05–2.95) | 14/61 | 1.64 (0.82–3.26) | |||||
| hsa-miR-204 | rs7861254 | GG | 37/106 | 1.00 | 0.04 | 28/166 | 1.00 | 0.77 | 0.3 |
| vs. GG | 70/306 | 0.62 (0.39–0.99) | 23/144 | 0.91 (0.5–1.67) | |||||
| hsa-miR-608 | rs4919510 | CC | 43/153 | 1.00 | 0.42 | 41/204 | 1.00 | 0.03 | 0.18 |
| CG/GG | 64/259 | 0.83 (0.54–1.29) | 10/106 | 0.45 (0.21–0.94) | |||||
| hsa-miR-758 | rs7141987 | AA | 2/19 | 1.00 | 0.36 | 8/94 | 1.00 | 0.03 | 0.83 |
| AG/GG | 104/392 | 2.01 (0.45–8.93) | 43/210 | 2.41 (1.08–5.37) | |||||
| hsa-miR-495 | rs2281611 | CC | 62/233 | 1.00 | 0.92 | 15/151 | 1.00 | 0.01 | 0.03 |
| CA/AA | 45/179 | 0.98 (0.63–1.51) | 36/159 | 2.29 (1.19–4.39) | |||||
| hsa-miR-513a-2 | rs2018562 | AA | 25/143 | 1.00 | 0.03 | 26/178 | 1.00 | 0.33 | 0.46 |
| AG/GG | 82/268 | 1.74 (1.06–2.86) | 25/132 | 1.35 (0.74–2.47) | |||||
*
Footnote: Odds ratios and p-valuesadjusted for age, body mass index (BMI), proportion of European ancestry, family history of breast cancer, and education.
Abbreviations: OR: odds ratio; CI: confidence interval; ER: estrogen receptor