Skip to main content
. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: J Am Chem Soc. 2013 Aug 1;135(32):10.1021/ja405106u. doi: 10.1021/ja405106u

Figure 1.

Figure 1

Synthesis of bicyclic peptide library. Reagents and Conditions: (a) Standard Fmoc/HATU chemistry; (b) soak in water; (c) 0.4 equiv Fmoc-OSu in Et2O/CH2Cl2; (d) di-t-butyl dicarbonate; (e) piperidine; (f) 4-hydroxybenzoic acid/HBTU/HOBT; (g) Fmoc-β-Ala-OH/DIC; (h) 50% TFA in DCM; (i) split-and-pool synthesis by Fmoc/HATU chemistry; (j) 2% TFA in DCM (6x); (k) Fmoc-OSu/ DIPEA in DCM; (l) Pd(PPh3)4; (m) diallyl protected trimesic acid/HATU; (n) PyBOP/HOBT/DIPEA; (o) modified reagent K.